Is Blood Plasma Used In Cosmetics? - 2023, Gabriela Margall

Is Blood Plasma Used In Cosmetics
What is PRP? – PRP is a form of cosmetic injectable treatment that uses the client’s own platelet rich plasma. The plasma component contains stem cells and growth rich platelets. When injected back into the skin, it accelerates the body’s natural production of collagen and elastin to provide overall skin rejuvenation. Firstly, a topical anaesthetic is applied to the area that will be treated. Secondly, our clinician will draw a small sample of blood. This is then spun in a centrifuge for approximately five minutes to separate the plasma from the other blood particles. Lastly, the platelet rich plasma is then reinjected back into the treatment area, stimulating collagen and elastin production.

Is blood plasma used in makeup?

Platelet-Rich Plasma is an extract of the patient’s own blood that has been enriched with platelets. As an autologous (patient’s own blood) source of platelets, PRP has been used in cosmetics to enhance skin repair and regeneration and volume correction, resulting in smoother, youthful skin.

Is plasma used in beauty products?

Pilot study: Autologous platelet‐rich plasma used in a topical cream for facial rejuvenation J Cosmet Dermatol.2019 Oct; 18(5): 1348–1352. Published online 2019 Jul 26. doi: PMCID: PMC6852537 1 Dermatology Consulting Services, PLLC, High Point North Carolina Find articles by 2 Department of Research and Development, Aesthetics Biomedical, Inc, Phoenix Arizona Find articles by 2 Department of Research and Development, Aesthetics Biomedical, Inc, Phoenix Arizona Find articles by 3 Development Engineering Sciences, LLC, Flagstaff Arizona Find articles by 3 Development Engineering Sciences, LLC, Flagstaff Arizona Find articles by Received 2019 Jun 22; Accepted 2019 Jun 26.

© 2019 The Authors.
Journal of Cosmetic Dermatology Published by Wiley Periodicals, Inc.
This is an open access article under the terms of the License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Platelet rich plasma (PRP) is traditionally used as an injectable material for enhanced healing, hair growth, and facial rejuvenation.

This research examined the novel use of topical autologously sourced PRP added to a preservative cosmetic base and applied twice daily to the face following electroporation for 8 weeks.20 healthy female and male subjects 30‐60 years of age were enrolled in this single‐site, investigator blinded, vehicle controlled split‐face study to evaluate the effect of a PRP‐containing serum versus the serum alone on facial photoaging.90 day stability for the PRP in a preservative serum was achieved with refrigeration at 4 degrees Celsius.

Facial skin biopsy histologic findings included improved rete peg architecture.
Immunohistochemical analysis showed upregulation for collagen type I with qPCR data demonstrating concomitant upregulation of mRNA for collagen after 8 weeks of topical PRP use.
These pilot study findings may indicate value for topical PRP in facial rejuvenation.

Keywords: aging skin, cosmetics, facial rejuvenation, platelet‐rich plasma, PRP The basic human need to look young has led to many concepts in facial rejuvenation. One such concept is the adaptation of platelet‐rich plasma (PRP) for dermatologic uses.

PRP was originally developed to improve healing in orthopedic and dental surgery, but is now used in plastic surgery via injection for wound healing and hair growth., The next horizon is the adaptation of PRP for topical uses in cosmetic formulations.
Platelets are composed of a cytoskeleton and intracellular structures such as glycogen, lysosomes, and two granules, the dense granule and the alpha‐granule.

The granules are the most valuable structures for the development of the current topical product. The dense granule has adenosine diphosphate (ADP), adenosine triphosphate (ATP), serotonin, and calcium, while the alpha‐granule contains clotting factors, growth factors, and proteins.

The main goal for the topical product is to keep the enclosed cellular components active throughout the intended time period of use and obtain enough platelets to be considered platelet‐rich plasma.
The normal platelet count in human blood is 150 000‐350 000/microliter.
PRP is defined as 1 000 000 platelets per microliter in a small volume of plasma with a full complement of clotting factors.

There are seven key growth factors in PRP: platelet‐derived growth factors (PDGFaa, PDGFbb, PDGFab), transforming growth factors (TGF‐b1, TGFb2), vascular endothelial growth factor (VEGF), and epithelial growth factor (EGF). These growth factors are found within a normal clot composed of fibrin, fibronectin, and vitronectin, which are cell adhesion molecules required for cell migration, as seen in wound healing.

Cellular mitogenesis and angiogenesis are both upregulated by PRP, making it useful in facial rejuvenation.
Autologous PRP is obtained from freshly drawn blood from the patient with an added anticoagulant and the sample then experiences a series of two centrifugation (spin) steps.
The first spin, known as the hard spin, separates the red blood cells from the plasma containing the platelets, white blood cells, and clotting factors.

Three layers result from the hard spin: an upper layer containing platelets and white blood cells, a middle layer known as the buffy coat containing white blood cells, and a bottom layer containing red blood cells. The red blood cell layer is removed and discarded.

The second spin, known as the soft spin, separates the platelet‐rich plasma in the bottom of the tube from the platelet‐poor plasma (PPP) in the top of the tube by removing more red blood cells. Proper preparation and centrifuge technique is critical to obtaining high quality active PRP. The literature has pointed to some preparations of PRP having a lack of biological effect which may be due to poor PRP processing or inadequate standard laboratory centrifuges that cannot properly prepare PRP rather than the specialized FDA cleared equipment with validated processes.

Platelet‐rich plasma is autologous, thus concerns about immune rejection are a nonissue. Growth factors function by activating a cytoplasmic signal that promotes normal gene expression. PRP contains the same materials present in the blood stream that induce clotting, except in higher concentration.

Platelet‐rich plasma works through degranulation of the alpha granules in platelets, which contain the growth factors. It is ideal to collect PRP in an anticoagulated state for the growth factors to remain active explaining the need to draw the blood into a tube containing sodium citrate. The biologically active cellular components such as the growth factors as preserved within the platelet when the platelet is held in an inactive state; premature degranulation does not occur, and therefore the cellular components are held within the protective enclosure of the platelet.

Upon activation of the platelet, the granules then fuse to the cell membrane, the degranulation process, activating the secretory growth factors, which bind to the transmembrane receptors of target cells, such as mesenchymal stem cells, fibroblasts, endothelial cells, and epidermal cells.

This binding activates intracellular signal proteins that express a gene sequence directing cellular proliferation, collagen synthesis, extracellular matrix formation, and numerous other pathways to promote healing and repair processes.
Damaged platelets with degraded or not viable cellular components are incapable of inducing this response.

The current pilot study examined the use of an autologously sourced PRP added to a preservative cosmetic base and applied twice daily to the face following electroporation for 8 weeks. Visual, photographic, histologic, immunohistochemical, and molecular qPCR data were obtained to better understand the role of topical‐administered PRP in facial rejuvenation.

Twenty (20) healthy female and male subjects 30‐60 years of age were enrolled in this single‐site, investigator blinded, vehicle‐controlled split‐face study to evaluate the effect of a PRP‐containing serum on facial photoaging. Subjects who signed consent and met all inclusion criteria and none of the exclusion criteria were enrolled at the baseline visit (Allendale Institutional Review Board, Old Lyme CT).

Subjects were asked to continue their self‐selected cleanser and nonmedicated facial cosmetics throughout the 8‐week study. Subjects were randomized to apply the PRP‐containing serum to the right or left face and the serum alone to the opposite side of the face.

Dermatologist investigator and subject assessments for efficacy and tolerability were conducted on a 5‐point ordinal scale (0 = none, 1 = minimal, 2 = mild, 3 = moderate, and 4 = severe) separately for each cheek. The following efficacy parameters were assessed: dryness, lack of tactile smoothness, lack of visual smoothness, lack of softness, lack of luminosity, lack of radiance, lack of firmness, poor skin texture, fine facial lines, wrinkles, poor skin tone, mottled hyperpigmentation, and overall appearance.

Tolerability was assessed in terms of itching, stinging, burning, redness, and swelling. Transepidermal water loss (TEWL) was performed from the right and left cheeks (Cyberderm, Broomall, PA) and Visia CR 4.3 (Canfield Scientific) photography of the front, right, and left sides of the face were completed before any treatments as baseline documentation.

All these activities were repeated at week 4 and week 8.
Subjects underwent phlebotomy to harvest 50ml of blood drawn into a tube containing 10 mL of anticoagulant (EmCyte Corporation), which underwent double centrifugation (EmCyte Executive Series Pure PRP Centrifuge, EmCyte Corporation) to yield 6‐9 mL of PRP.

The PRP was added to the serum and applied to one randomized side of the face with the opposite side receiving the serum alone. To enhance penetration of the PRP, subjects underwent electroporation with a hand‐held electroporation device (RUMI, SheNB Ltd) for 5 minutes to the cheeks, forehead, and periocular area.

The study subjects were instructed to keep test articles refrigerated at all times.
Subjects were dispensed a sunscreen containing SPF30 moisturizer (Eucerin Daily Protection Face Lotion, Beiersdorf) and a compliance diary.
A subset of 4 subjects participated in the biopsy sub‐study undergoing a 2 mm punch biopsy from the left and right preauricular areas, following anesthesia with 2% lidocaine plus epinephrine.

The specimens were processed, sectioned, and hematoxylin and eosin (H&E) stained. H&E stained 5 µm serial sections from paraffin blocks and were digitally scanned (NanoZoommer, Hamamatsu). Length profile measurements of the stratum basale and stratum granulosum layers of the epidermis were obtained, generating a ratio between basale/granulosum layers.

Nuclear counting and epithelial thickness measurements were conducted.
Quantitative immunohistochemistry analysis for collagen I, and elastin were quantified using a color deconvolution algorithm from digitally scanned immunohistochemistry slides.
Quantitative polymerase chain reaction was conducted analyzing Collagen 1A1 (COL1 A), keratinocyte proline rich protein (KPRP), and matrix metalloproteinase 1 (MMP1) genes.

Quantitative PCR (qPCR) was performed on biopsy tissue samples that were preserved in RNA later solution. Fold change in mRNA expression between treatment and control for each subject was calculated using the following equation: An average fold change of 2 represents a significant upregulation in gene expression, and a 0.5‐fold change represents a twofold decrease (downregulation) in gene expression.

Next, the opposite integer of the ∆∆ C T value was determined.Lastly, an average FC was calculated for the specific probe analysis according to the following formula: Average FC = 2 x ¯, where x ¯ is the average of the −ΔΔ C T values.

Ordinal investigator and subject nonparametric data were analyzed using a Mann‐ Whitney paired two‐tailed analysis evaluating change from baseline comparing the active PRP + serum‐treated side of the face to the serum‐only treated side of the face. The parametric TEWL, histology, and immunohistochemistry data were analyzed using a paired Student’s t test ( P ≤,05). All 20 subjects in the main study and 4/4 subjects in the biopsy sub‐study successfully completed the study. No tolerability issues were noted by either the blinded investigator or the subjects with either the PRP + serum or the serum alone. This was confirmed by the lack of change in TEWL readings from both sides of the face. In addition, no statistically significant differences between the PRP + serum treatment or the serum alone treatment were noted by either the blinded investigator or the subjects after 8 weeks of use in any of the assessed parameters. Both sides of the face demonstrated statistically significant ( P <,001) improvement for dryness, tactile smoothness, visual smoothness, softness, luminosity, and radiance at 8 weeks. PRP + serum did demonstrate directional improvement of radiance, luminosity, smoothness at 4 weeks, increasing at 8 weeks vs the serum alone. The histopathology findings demonstrated a qualitative improvement in the PRP + serum‐ treated group with a trend of greater rete peg presence in the PRP + serum group compared with base serum controls (Figure ). Immunohistochemistry revealed enhanced Collagen type I expression in the serum + PRP treatment versus the serum without PRP (Figure ). These collagen findings were further supported by the qPCR data. Three target genes (collagen IA, matrix metalloproteinase 1 gene, and keratinocyte proline rich protein) and a housekeeping gene control was evaluated. Results demonstrated a 2.34‐fold increase in collagen gene upregulation in the PRP treatment serum vs. control serum for collagen type I (Table ). Samples form subjects 2 and 4, produced sampless that did not produce threshold counts; consequently, a fold change could not be determined. Summary of Q‐PCR Analysis


Summary of Q‐PCR Analysis
	Col‐1A (FC)	KPRP (FC)	MMP‐1 (FC)
Subject 1	1.31	0.83	0.227
Subject 2	8.53
Subject 3	1.87	1.03	9.39
Subject 4	1.44	1.09
Average (FC)	2.34	0.98	1.45

Is blood plasma good for skin?

1. Stimulate Collagen Production – Vitamin C is an antioxidant, meaning it defends your skin from free radicals that can harm your skin. With regular use, vitamin C can help heal blemishes, reduce hyperpigmentation, and keep your skin from sagging. To maintain a bright, even-toned, refreshed look, Dr.

Lilly Parllaku recommends adding vitamin C to your skincare routine.
Plasma-rich therapy treatment can dramatically reverse years of skin damage in one session.
By penetrating deep into the dermis to stimulate collagen production and connective tissue regeneration, skin will tighten and appear more lifted post-treatment.

At Bryn Mawr Dermatology, we often recommend combining platelet-rich plasma therapy with other treatments for the best results. Plasma-rich therapy combined with fractional C02 laser, microdermabrasion, or microneedling can dramatically improve scar depth and skin texture.

Many people between the ages of 18 to 30 struggle with acne.
If you are looking to alleviate the damage caused by acne, consider PRP acne scar injections.
These injections contain a concentration of platelets, growth factors, stem cells, and other components which initiate neocollagenesis – the process of forming new collagen.

By inserting the PRP serum under the scars, dermatologists can reduce skin depressions and stimulate new collagen production.

What is plasma used for in beauty treatment?

Platelet Rich Plasma — Cosmetic Laser Clinic PRP has become a highly sought-after non-surgical procedure for facial and skin rejuvenation. PRP therapy is a treatment which uses your own blood platelets to stimulate new cell growth, helping to improve your complexion, skin texture and to restore lost facial volume.Your blood is essentially made up of four components; red blood cells, white blood cells, the plasma and the platelets.

We take your blood and spin it in a centrifuge, which enables the separation of the blood cells from your plasma and platelets.
This is then re-injected into the skin to stimulate collagen and new skin cells.
PRP harnesses the beneficial functions of the patients own platelets and therefore there is no risk of allergy or rejection of the treatment.

PRP can also be successfully used to treat thinning hair and hair loss particularly male pattern baldness. It is important to start treatment early on and whether you are a suitable candidate will be determined during your consultation.

Can you use plasma instead of serum?

Abstract – The relative merits of plasma and serum in blood analysis are reviewed. The expression ‘plasma concentration’ is often used in the literature, although serum samples have been taken. In most cases serum and plasma concentrations of analytes are the same.

Is plasma better than serum?

What’s the difference between Plasma & Serum? – A key difference between plasma and serum is that plasma is liquid, and serum is fluid. While most of the components are the same for both plasma and serum, plasma contains fibrinogen which is absent in serum.

Both plasma and serum can be extracted from blood with the use of a centrifuge but it’s worth noting that serum is obtained after the clotting of blood, while plasma can be obtained before the coagulation of the blood.
Serum is mostly used for blood typing but is also used for diagnostic testing.
Plasma, on the other hand, is mostly used for blood-clotting related problems.

What products are made with plasma?

It’s used in pharmaceutical products

Plasma-based product	Used for
Intramuscular Immunoglobulin	Immunisation against hepatitis A, measles and poliomyelitis
Albumin	Treating patients suffering from shock due to blood loss
Intravenous Immunoglobulin IVIg	Treating some primary immune deficiency disorders

Is plasma safe for face?

What You Need to Know About the Platelet-Rich Plasma Facial Is Blood Plasma Used In Cosmetics People who are interested in improving the appearance of their skin have no shortage of facial treatments from which to choose. If you follow celebrities on Instagram, you may have heard about something called a platelet-rich plasma facial. It is a treatment in which platelet-rich plasma (PRP) is drawn from your blood and applied to your face.

Im Kardashian posted a picture of herself trying the treatment in 2013, which helped popularize the concept. Covering your face in blood may seem like an extreme way to rejuvenate the skin. But platelet-rich plasma facials may provide some dermatological benefits — helping smooth the skin and minimize the appearance of wrinkles and scars for a more youthful look.

Most individuals can safely have a platelet-rich plasma facial. However, it’s important to understand the risks so you can make an informed decision. Here’s what you need to know.

What products is plasma used in?

Plasma Components Plasma is the aqueous part of blood containing proteins and salt in which red and white blood cells and platelets are suspended. It constitutes approximately 55 percent of total blood volume. Important elements in plasma include albumin, coagulation factors, fibrinolytic proteins, immunoglobulin and other proteins.

Plasma usually is frozen within hours of donation in order to preserve the clotting factors. Frozen plasma products have a 12-month life span and are transfused within 24 hours of thawing. Plasma products are indicated for use in several treatments, including to treat bleeding disorders when a patient is deficient in one or multiple clotting factors and no factor-specific concentrate is available, and initial treatment of patients who are undergoing massive transfusion because of life-threatening trauma/hemorrhages and who have clinically significant coagulation deficiencies.

Some plasma products are not used for direct transfusion but are shipped for further manufacture where they are separated into specific products, including albumin, clotting factors and intravenous immune globulin. AABB works on behalf of donors and patients to ensure the safe and effective collection, processing and use of plasma.

Is plasma better than Botox?

The Difference Between Plasma Pens And Botox Treatments – While both of these skin rejuvenation therapies work to tighten the skin, they have different ways to go about it. Here’s a quick table to compare and contrast:

Plasma Pens	Botox Injection
Requires some degree of post operative care	Requires very little pre and post operative care
Ideal for use on small patches of the skin	Ideal for use on facial lines
Has less side effects than Botox	Has more side effects than plasma pens
Best results obtained in one to two weeks	Best results obtained 30 minutes after the procedure
Uses physical ablation	Uses chemical control
Relatively new, hard to access for more cosmetic practices	Accessible to most cosmetic practices

These treatments are generally most used on the areas of the face that have the most wrinkles and folds like the lips, eyes, and mouth. They also share several side effects like numbing, light scarring, and inflammation. Overall, Botox may cost less, but doesn’t stick around for long.

Is PRP better than fillers?

PRP Is All-Natural – PRP is also an, However, the product we inject is entirely natural because it is made from your own blood. There is no risk of allergic or other adverse reaction. The procedure is simple and doesn’t take much time. We take a small sample of your blood, then spin it in a centrifuge to separate the platelets – proteins that contain the growth factors essential for healing.

We refine that concentrated platelet serum and carefully inject it in precisely the right spots to achieve your desired results.
The results are all-natural, too.
Unlike a filler product that is gradually absorbed by your body, the platelet-rich plasma stimulates your body’s own production of localized blood vessels and new skin cells with healthier collagen structure.

It can take a little longer to see your new look, as takes time, so while you will see improvement right away, fully visible results may take a few weeks. If PRP is accidentally injected into a vessel under your eye, the risk of blindness is essentially zero.

What are the risks of blood plasma?

Potential Side Effects – The U.S. Food and Drug Administration regulates plasma collection in the United States. For most people, donating plasma does not cause any side effects, but some donors can experience fatigue, bruising, bleeding, or dehydration.

Additionally, you may feel dizzy or lightheaded.
While not typical, fainting can also occur.
It’s rare, but more serious infections or reactions can occur, which can be treated.
If you experience severe symptoms, contact a doctor immediately.
If you experience general side effects, it can help to rest, drink more water, and eat more iron-rich foods.

For dizziness or fainting, lie down or sit with your head between your knees. For bleeding, raise your arm, apply pressure, then place a bandage over the area for several hours.

What is plasma in aesthetics?

Plasma Blast St Helens What is Plasma Blast? – Plasma (Fibro) Blast is a revolutionary new treatment which is extremely effective. Non-surgical treatment which is designed to improve the texture and tone of the skin, effectively tightening the skin which results in the removal of wrinkles and stretch marks and in many cases the skin is left looking amazing. Is Blood Plasma Used In Cosmetics

What is plasma in face cream?

Platelet-rich plasma (PRP) is known as a “natural filler” treatment that gives a more youthful appearance to the skin with minimal downtime. There are virtually no risks of allergies or sensitivity as PRP is derived from your own blood. PRP is actually blood plasma containing high concentrations of platelets that stimulate stem cells to help the body regenerate and heal at a faster rate.

PRP improves overall skin texture, decreases the appearance of fine lines and wrinkles around the mouth and eyes, and plumps hollowing areas such as tear trough grooves, cheeks, and temples. PRP can also help smooth both acne and surgical scars. Overview of the PRP Treatment PRP Facial Rejuvenation takes about an hour to complete.

A topical numbing cream may be applied 1 hour before the treatment to the treatment area to minimize discomfort during the procedure. Next, 1-4 vials of blood are drawn and centrifuged to separate out a layer of concentrated plasma rich cells, platelets and growth factors. Is Blood Plasma Used In Cosmetics Results PRP facial rejuvenation naturally stimulates your body’s own collagen production, and it takes about three months for maximum collagen regeneration to occur. Most patients notice an improvement in their skin texture in the first month after the treatment.

It is recommended to have 2-3 treatments spaced at 6- 8 week intervals. The results of PRP rejuvenation are long term with most patients receiving touch up treatments at one year to further stimulate collagen production and continued facial rejuvenation. For more immediate improvement, we can combine the benefits of the PRP facial rejuvenation with Botox, fillers, microneedling, and laser skin resurfacing.

Risks and Recovery PRP Facial Rejuvenation is one of the lowest risk treatments because the process involves injecting a substance sourced from your own body. Mild injection site bruising, swelling or redness can occur but usually resolves after 3-7 days following the procedure and may be safely concealed with make-up shortly after the treatment.

Do Not take Aspirin, unless prescribed, for at least 1 week before the procedure. For optimal results and to decrease the chance of bruising at the draw site, please avoid all non-prescribed blood thinning medications and herbal supplements for 1 week prior to your appointment. Avoid taking non-prescribed Fish oil, Aspirin, and other non-steroidal anti-inflammatory medications (NSAIDS) such as such as Ibuprofen, Motrin and Aleve. Please notify your provider if you are taking Coumadin, Plavix, or any other blood thinners for any medical conditions. AVOID ALCOHOLIC beverages the day before your treatment, as they can cause dehydration, and increase the risk of bruising. Diet before Procedure : You should have a light meal before arriving at the office and avoid caffeine. HYDRATE: You should drink at least 8 glasses of water 24 hours before your treatment and at least 12 ounces of water the morning of your treatment. Failure to come hydrated may result in suboptimal blood draw.If we are unable to draw your blood because you did not properly hydrate, then your appointment may be rescheduled and subject to cancellation fees.Avoid makeup, retinoids, glycolic acids, vitamin C products for 1 week before your procedure.

Post care for injection of PRP For 3 days after the procedure:

DO NOT apply makeup DO NOT touch the injection site, except for gentle cleansing DO NOT swim or undertake in any strenuous exercise DO NOT expose yourself to long periods in the sun DO NOT sit in a sauna, hot tub, or Jacuzzi DO NOT expose yourself to extreme hot or cold temperatures, or to large swings in temperature Use only gentle skin care products to wash the treated area for the first 3 days such as Cetaphil gentle cleanser. After that you can resume normal skin care.Oxygenetix post procedure makeup with sun screen is recommended as coverup makeup (if needed post-procedure).

For treatments involving the face or lip area:

DO NOT drink very hot or cold beverages for 3 days. DO NOT undergo other cosmetic treatments such as chemical peels, laser treatments, etc. for at least one month.

Post care for topical application of PRP (combined with microneedling or laser)

DO NOT wash your skin for 5 hours after treatment. DO NOT swim or undertake in any strenuous exercise or activity that may cause sweating for 5 hours; DO NOT expose yourself to the sun for 5 hours.For best results and efficacy: We recommend a series of 3-6 treatments administered at 6-8 week intervals. You may notice immediate as well as longer term improvements in your skin.

Potential Side Effects : In some very rare cases, slight side effects may occur: redness, local swelling, edema, local pain. These should not last more than a few hours, but can last up to a few days. These are normal treatment consequences. In case of local infection, antibiotics may be prescribed.

How often should I do plasma on face?

How often to get treatments – Microchanneling with PRP can be performed by itself or in combination with other noninvasive treatments. How many sessions we schedule is based on your current skin condition and cosmetic goals. Dr. Anees and the trained team at Med Spa at Seena One (Corrective Skin Care)develop personalized Vampire Facial benefits to match these needs.

Is blood serum the same as blood plasma?

The Importance of Clotting – The clotting process activates a cascade of proteases, which results in the conversion of prothrombin to thrombin, an enzyme that converts fibrinogen into fibrin to clot blood. Platelets are activated in the process and release a set of compounds, which naturally alters proteins in the serum.


Type	Definition	How it’s Obtained	Appearance	Density	Composition	Common Uses
Serum	Liquid that remains after the blood has clotted	Centrifuging clotted blood	Light yellow, clear	1.024 g/ml	Water, albumin, globulins, amino acids, hormones, enzymes, nitrogenous waste, nutrients, gases. Higher in TFGbeta, VEGF and IL-8.	Blood typing, diagnostic testing, supplementation of culture medium, testing for antibodies
Plasma	Liquid that remains when clotting is prevented	Centrifuging while blood with anticoagulant	Light yellow, clear	1.025 g/ml	Water, albumin, globulins, amino acids, hormones, enzymes, nitrogenous waste, nutrients, gases, fibrinogen. Dependent on anticoagulant used. Low Ca++, Mg++ in EDTA and citrate plasma. Lower Levels of inflammatory mediators	Blood typing, diagnostic testing, supplementation of culture medium, testing for antibodies

Why is serum preferred over plasma?

Samples for Chemistry In general, serum samples (red top tubes) are preferred for chemistry testing. This is because our chemistry reference intervals are based on serum not plasma. In general, there is little difference between serum and plasma, except for certain analytes.

For example, LDH, potassium and phosphate are higher in serum than plasma, because of release of these constituents from cells during clotting.
Protein and globulins are higher in plasma than serum, because plasma contains fibrinogen.
The disadvantage with serum is that the samples can take a while to clot, therefore for late afternoon samples (after 3 pm Monday to Friday, after 12 pm Saturday), collection into heparin (green top tube) is advised to expedite sample handling.

All stats for chemistry should be submitted in heparin so that we do not have to wait for the blood to clot. Citrate (blue top) and EDTA (lavender top) cannot be used for chemistry panels because they chelate minerals (e.g. calcium) and interfere with the tests.

Furthermore, citrate dilutes the sample.
We recommend that from an individual patient, samples for chemistry should always be collected into the same tube (heparin or red top) for the duration of the patient’s stay in hospital.
This will ensure that changes in analytes are patient- or disease- and not anticoagulant-related.

For example, if the first chemistry panel is submitted in heparin, all subsequent chemistry tests should be submitted in heparin to allow more valid comparison between sequential results.

What are two differences between blood plasma and serum?

Difference between Plasma and Serum – Serum and plasma are obtained from the liquid portion of the blood that is obtained when the cells are removed. However, there is striking difference between plasma and serum. Serum is the liquid that remains after the clotting of blood.

Plasma	Serum
A transparent, straw-coloured, liquid portion of the blood.	An undiluted fluid, the extracellular portion of blood.
It is composed of serum and clotting factor.	It is the part of the blood which lacks clotting factor.
It is acquired after centrifuging blood with the anticoagulant.	It is acquired after centrifuging of coagulated blood.
Anticoagulant is required to obtain plasma from the blood sample.	Anticoagulant is not required to separate the serum from the blood sample.
Consists of 55% of the total volume of blood.	Less volume in comparison to plasma.
Comparatively easier and less time is required to separate the plasma from the blood sample.	Difficult to separate serum from the blood sample. It is a time-consuming process.
Contains fibrinogen.	Lacks fibrinogen.
Consists of 92% water with proteins, salts, lipids, and glucose.	Consists of 90% water with dissolved hormones, proteins, minerals, and carbon dioxide.
Has 1.025 g/ml density	Has 1.024 g/ml density.
Has a long shelf life. It can be preserved up to ten years.	Has a short shelf life. It can be preserved only for a few months.
Plasma is the main medium for excretory product transportation.	An important source of electrolytes.
Cells are freely suspended in plasma.	Cells are attached together by clot formation.

What is better than plasma?

OLED – The OLED technique for televisions is still relatively new. The latest generation of screens all have a 4K resolution. In addition, they’re very suitable for watching movies and series in HDR. With an OLED, you’re ready for the future of television. Want to see the difference between plasma and OLED yourself? Visit one of our stores. Our colleagues are happy to show you all of the differences. Click the button below for an overview of all Coolblue stores. : Compare a plasma TV to an OLED TV

Is plasma more valuable than blood?

Compensation – Besides being able to help others, another benefit to donating plasma is that you can get compensated for your time. Unlike full-time jobs or part-time gigs, there are no commitments and how often you donate is completely up to you. As long as you go to a plasma collection center—not a blood center—you can earn as much as $40-$50 per visit.

At Parachute, our app makes it easy (and fun) to maximize your earnings through new member bonuses, challenges, referrals, and time incentive bonuses. Frequent plasma donors can easily earn thousands of dollars per year while helping others. Unfortunately, whole blood donors do not get compensated for their time.

Whether you’re donating at a mobile blood drive or a nearby blood bank, there is no payment for your donation.

Is plasma more stable than serum?

There are also differences in stability of analytes with serum typically being the more stable of the two sample matrixes. Plasma tends to be less stable because of the cellular debris.

Is plasma safe for face?

Kim Kardashian posted a picture of herself trying the treatment in 2013, which helped popularize the concept. Covering your face in blood may seem like an extreme way to rejuvenate the skin. But platelet-rich plasma facials may provide some dermatological benefits — helping smooth the skin and minimize the appearance of wrinkles and scars for a more youthful look.

Most individuals can safely have a platelet-rich plasma facial. However, it’s important to understand the risks so you can make an informed decision. Here’s what you need to know.

What products is plasma used in?

It’s used in pharmaceutical products

Plasma-based product	Used for
Intravenous Immunoglobulin IVIg	Treating some primary immune deficiency disorders
Antithrombin concentrate	Preventing blood clots during surgery or childbirth
Factor IX concentrate	Treating patients with inherited bleeding condition haemophilia B

What products are made with plasma?

1. Albumin – Albumin is a water-soluble protein that is produced by the liver and circulates in plasma, making up a total of half of the protein content in this liquid. Medicinal albumin is made from source plasma that is heated to inactivate disease-causing agents.

Can you use blood serum for face?

What Are the Benefits of SoME® Skincare? – SoME® Skincare products restore and rejuvenate skin through a mix of PRP and other anti-aging ingredients. SoME® Skincare blood-enhanced serums can treat wrinkles, restore skin tone, smooth skin, and more. These products use the patient’s growth factors and biomolecules to reverse the effects of aging.

Using the patient’s blood also reduces the chance of allergic reactions that other topical skin serums can cause.
Since the blood-enhanced serum is partially created from the patient’s blood, it is automatically suitable for treating that patient’s skin type.
This means that SoME® Skincare products are inherently personalized for each of your patients.

Better yet, these products do not require in-office treatments. While the serum must be extracted at a doctor’s office, the actual blood-enhanced serum can be stored at home by patients and administered over time. SoME® Skincare products provide personalized, high-quality skincare treatments to patients and give doctors a powerful tool to treat skin conditions associated with aging.