Is Edta Harmful In Cosmetics? - [] 2023: Gabriela Margall

Is Edta Harmful In Cosmetics
Where does it come from? – EDTA is a synthetic ingredient. It is formulated in the laboratory. EDTA acts as a chelator. It “grabs” metal ions that can affect the stability and / or appearance of cosmetic products. EDTA is used to counter the hardness of water in rinse-off products. It helps avoid the precipitation of certain ions (calcium, magnesium.) in order to ensure the quality and preservations of products.

Grabs metal ions Avoids the precipitation of certain ions

EDTA may cause irritation when in contact with the eyes and eczema. There are some concerns regarding the persistence and bioaccumulation in the environment, given the widespread use of EDTA. Facts:

EDTA is safe for use in cosmetics, and for decades the data is well-reported. At the concentration level as it is used in our products, EDTA is a well-tolerated ingredient and allergic cases are very rare.

Is EDTA toxic on skin?

In several studies, the Cosmetics Review Board has found that as used in cosmetics products, disodium EDTA is safe. It was determined that in the concentrations used in commercial cosmetics, it is not a skin sensitizer nor a carcinogen, and does not penetrate through skin.

What are the side effects of EDTA in cosmetics?

– Should you have any overexposure to the ingredient (more than 3g of disodium EDTA per day), take note of the side effects as follows, as noted in multiple studies.Too much of disodium EDTA can cause multiple side effects, including nausea, vomiting, diarrhea, low blood pressure, fever, and skin issues.

Disodium EDTA also found to cause interference with blood sugar management in diabetics as it can interact with insulin, affecting heart rhythm for anyone having irregular heart rhythm, and even making breathing tubes narrow due to nebulizers that are containing disodium EDTA as part of their ingredient, as well as issues with reproductive organs.

Since disodium EDTA is also working as a chelating agent, it can be dangerous when there’s an excess in the bloodstream as the ingredient can bind with potassium, increasing the concentration of the mineral to be flushed out through kidney. This, in turn, causes your body to have way low of the mineral, especially if you have it too low to begin with.

A similar mechanism also applies to calcium and magnesium, causing your body to have the mineral too low, creating hypocalcemia (increasing the risk of getting seizures) and mineral imbalances worse.
If you exceed than maximum limits, serious side effects include severe kidney damage, mineral imbalance in the bloodstream, and even death.

While disodium EDTA is deemed safe for use and consumption, we should be aware of the danger of overexposure and taking necessary steps to avoid getting one. After all, since the ingredient is pretty much everywhere, we need to be extra careful with products that we are using, slowly making our way to reduce the exposure to the ingredient to the bare minimum.

Is EDTA a safe ingredient?

EDTA is a molecule called a chelating agent. A chelating agent is a claw-like substance that can grab and stick to other molecules. Some types of EDTA stick to calcium, Other types stick to metals, such as lead. EDTA is sometimes prescribed by doctors to clean toxic metals, such as lead, from the blood,

Doctors have used the molecule for decades to treat heavy metal poisoning.
In those cases it is given through an IV.
EDTA is also an ingredient in some prescription cancer -fighting medicines.
Supplement makers claim that over-the-counter forms of EDTA can be taken by mouth to “detox” the body and make your gastrointestinal tract healthier.

There is no scientific evidence to support this. Preliminary studies show that intravenous EDTA therapy under physician supervision may help patients who have had a heart attack, particularly if they have diabetes. However, more study is needed to prove this.

DiabetesPeripheral vascular diseaseAlzheimer’s disease

However, evidence is lacking that EDTA works for those conditions. Optimal doses of EDTA supplements have not been set. Supplement ingredients and quality may vary widely. This makes it hard to set a standard dose. EDTA is a chemical that is added to certain foods and beverages to help them keep their color and flavor. For instance, it is sometimes added to:

SodasCanned fruits and vegetables Non-nutritive sweeteners Condiments such as mayonnaiseSalad dressings

The FDA says EDTA is considered safe for use in foods in the U.S. The most common side effect of EDTA is burning at the IV site. Chelating agents can also have serious, even life-threatening side effects. One of the most serious side effects of EDTA is kidney damage and kidney failure. Other side effects that have been reported in patients taking some forms of EDTA have included:

Anemia Chills, fever, or headache Blood clot in a veinLower levels of magnesium and potassium in the blood Diarrhea, vomiting, or nausea Fatigue Abnormal calcium levels in the blood Insulin shockIrregular heartbeats, which can be severe Low blood pressure ThirstAching joints

EDTA supplements may interfere with medicines you are taking. EDTA can interact with:

Insulin Coumadin ( warfarin )

EDTA can also interact with diuretics (water pills). It may lead to dangerously low potassium levels. This can cause severe, irregular heartbeats. Make sure your doctor knows if you are taking any of these medicines. Talk to your doctor before taking EDTA if you take any medicines or have any medical conditions:

Asthma Diabetes Heart problems Kidney disease Liver disease, including hepatitisLow levels of calcium, magnesium, or potassium Seizure disorders Tuberculosis

Always tell your doctor about any medicines and supplements you are taking, including natural ones and those bought without a prescription. That way, your doctor can check on any potential side effects or interactions with any of your medicines or health conditions.

Is EDTA a carcinogen?

It’s carcinogenic, shown to induce tumours in mammary glands.

Is EDTA absorbed through the skin?

Abstract – EDTA (ethylenediamine tetraacetic acid) and its salts are substituted diamines. HEDTA (hydroxyethyl ethylenediamine triacetic acid) and its trisodium salt are substituted amines. These ingredients function as chelating agents in cosmetic formulations.

The typical concentration of use of EDTA is less than 2%, with the other salts in current use at even lower concentrations.
The lowest dose reported to cause a toxic effect in animals was 750 mg/kg/day.
These chelating agents are cytotoxic and weakly genotoxic, but not carcinogenic.
Oral exposures to EDTA produced adverse reproductive and developmental effects in animals.

Clinical tests reported no absorption of an EDTA salt through the skin. These ingredients are likely, however, to affect the passage of other chemicals into the skin because they will chelate calcium. Exposure to EDTA in most cosmetic formulations, therefore, would produce systemic exposure levels well below those seen to be toxic in oral dosing studies.

Exposure to EDTA in cosmetic formulations that may be inhaled, however, was a concern.
An exposure assessment done using conservative assumptions predicted that the maximum EDTA dose via inhalation of an aerosolized cosmetic formulation is below that shown to produce reproductive or developmental toxicity.

Because of the potential to increase the penetration of other chemicals, formulators should continue to be aware of this when combining these ingredients with ingredients that previously have been determined to be safe, primarily because they were not significantly absorbed.

Why is EDTA added to cosmetics?

Disodium EDTA in Skin Care: What It Is Good No known benefits

One of the salt forms of ethylenediaminetetraacetic acid Helps enhance the stability of cosmetics formulas Makes it easier for preservatives to do their job Safe as used in cosmetics (which is up to 0.85% in leave-on products) Is also used as a food additive

Disodium EDTA is a salt of ethylenediaminetetraacetic acid (commonly known as EDTA). In cosmetics, it functions primarily as a chelating agent, meaning it prevents ingredients in a formula from binding with trace elements (mainly minerals) that can be present in water or other ingredients.

This action enhances the stability of cosmetics formulas and helps makes the job of preservatives easier since EDTA ingredients bond with mineral ions that microorganisms need to remain intact. In addition to being used in makeup, skin care, and hair care products, disodium EDTA is also used as a food additive.

Cosmeticsinfo.org, Accessed November 2021, ePublication Cosmetic Ingredient Review, June 2019, pages 1-77 European Commission Directorate General for Health and Consumers, September 2015, ePublication

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region. : Disodium EDTA in Skin Care: What It Is

Is EDTA a hormone disruptor?

Is Edta Harmful In Cosmetics For the last few years, I’ve been slowly but surely transitioning into only purchasing all natural skincare and make up products. And and although it’s been easier since there have been so many incredible all natural beauty brands pop up in the last few years, it’s always hard to find products and skincare brands you call in love with.

To make it even more complicated, double checking to make sure your favorite products don’t have the harmful indredients is always important to keep your skin and makeup toxin free! A few weeks ago I went to the new Credo Beauty store in Bucktown and learned all about the harmful skincare ingredients you should always avoid when looking for beauty and skincare products.

Basically, you should always try to avoid these 5 things when looking at skincare and beauty products to make sure they’re worry-free!

Allergens: Ingredients that can cause an allergic reaction Frank Carinogen: A single ingredient listed on an ingredient label that can lead to or cause cancer Hidden Carcinogens: Ingredients that may, under certain conditions, have carcinogenic properties when combined with other ingredients in a product Hormone Disruptor: Chemicals that may interfere with the body’s endocrine system that products adverse developmental, reproductive, neurological, and immune effects. Penetration Enhancer: Ingredients that penetrate into skin to decrease the barrier to resistance.

Is Edta Harmful In Cosmetics When looking at specific products, here re the ingredients you should always avoid! I’ve been trying to keep tabs on checking all my old products and the new ones I’ve been buying too! Cleaners:

Benzalkonium Chloride (allergen) BHA (butylated hydroxyanisole) and BHT (butylated hydroxytoluene) (Frank Carcinogen) Coal Tar (Frank Carcinogen) 1,4-Dioxane (Hidden Carcinogen) Tetrasodium EDTA (ethylenediamineteraacetic acid tetrasodium salt) (Hormone Disrupter) Formaldehyde and formaldehyde-releasing preservatives (FRPs) (Frank and Hidden Carcinogens) Fragrance (Parfum) (Allergens, Hidden Carcinogen, Hormone Disruptor) Ethanolamines (DEA/TEA/MEA/ETA) (hidden carcinogen, penetration enhancer) Methyl Cellosolve (Hormone Disruptor) Methylisothiazolinone (also known as MI or MIT) and methylchloroisothiazolinone (also known as MCI) (Penetration Enhancer, Allergen) PEGs (polyethylene glycol) (Frank and Hidden Carcinogen) Petroleum and mineral oil derived ingredients (Frank and Hidden carcinogen) Parabens (Hormone Disruptor, Hidden Carcinogen) SLS (Sodium lauryl sulfate) and SLES (Penetration enhancer, Allergen) Triclosan (Penetration Enhancer, Allergen)

Color Cosmetics:

Oxybenzone (Allergen Penetration Enhancer) BHA (butylated hydroxyanisole) and BHT (butylated hydroxytoluene) (Frank and Hidden Carcinogen( BPA (Frank and Hidden Carcinogen) Coal Tar (Frank and Hidden Carcinogen) Tetrasodium ETDA (Hormone Disrupter) Ethanolamines (DEA/TEA/MEA/ETA) (Hidden Carcinogen, penetration Enhancer) Formaldehyde and formaldehyde-releasing preservatives (FRPs) (Frank and hidden Carcinogen) Mercury compounds (Thiomersal) (Frank and Hidden carcinogen) Phthalates (Frank Carcinogen, Hormone Disrupter) Parabens (Hormone Disrupter, Hidden carcinogen) PEGs (polyethylene glycol) (Frank and Hidden carcinogen)

Creams and Lotions:

Benzalkonium chloride (Allergen) BHA (butylated hydroxyanisole) and BHT (butylated hydroxytoluene) (frank and Hidden carcinogen) Coal Tar (frank carcinogen) 1,4-Dioxane (Hidden carcinogen) Ethanolamines (DEA/TEA/MEA/ETA) (Hidden Carcinogen and Penetration Enhancer) Formaldehyde and formaldehyde-releasing preservatives (FRPs) (Frank and Hidden Carcinogen) Methyl Cellosolve Methylisothiazolinone ( also known as MI or MIT) and methylchloroisothiazolinone ( also known as MCI) (Penetration Enhancer, Allergen) Mercury compounds (Thiomersal) (Frank Carcinogen] PEGs (polyethylene glycol) (Frank and Hidden carcinogen) Parabens (Hormone Disrupter, Hidden carcinogen) Petroleum and MIneral Oil derived ingredients (Frank and hidden Carcinogen) Tetrasodium EDTA (ethylenediaminetetraacetic acid tetrasodium salt) (Hormone Disruptor)

For Anti-Aging Products:

Hydroquinone (Frank Carcinogen) Methyl Cellosolve (Hormone Disruptor) Mercury compounds (Thiomersal) (Frank Carcinogen) Parabens (Hormone Disrupter, Hidden carcinogen) PEGs (polyethylene glycol) (Frank and Hidden Carcinogen) Petroleum and mineral oil derived ingredients (Frank and Hidden carcinogen)

Exfoliants and Masks:

1,4-Dioxane (Hidden Carcinogen) Tetrasodium EDTA (ethylenediaminetetraacetic acid tetrasodium salt) (Hormone Disruptor) Ethanolamines (DEA/TEA/MEA/ETA) (Hidden carcinogen, Penetration Enhancer) Fragrance (Parfum) (hidden carcinogen) PEGs (polyethylene glycol) (frank and Hidden Carcinogen) Petroleum and mineral oil derived ingredients (Frank and Hidden carcinogen) Parabens (Hormone Disruptor and Hidden Carcinogen)

Is Edta Harmful In Cosmetics Okay, I could go on forever, but if I’m missing any products you usually buy, check out the full list from Credo Beauty here ! I’ve been trying my best to reference all the ingredients in the products I’ve been purchasing – and also making sure that they’re vegan whenever possible too! My favorites as of late have been anything Tata Haper, One Love Organics and Cocovit – I’ve been trying to elicit some self control when it comes to buying skincare products, but I’m always a sucker for those brands 😉 Have any favorite all-natural beauty brands you swear by? I’m always willing to try something new over here!

Is EDTA used in Europe?

EDTA is used to clean scale deposits from internal boiler surfaces and as additive to incoming boiler feedwater to prevent the formation of calcium and magnesium scales. It is assumed that the 215 tonnes EDTA yearly used in Europe for this purpose are widespread and will not lead to a high local exposure.

Is EDTA inflammatory?

Discussion – Our results demonstrate that EDTA is toxic to the intestine when inflammation is present in doses that were not expected to cause any adverse effects. The addition of EDTA compounds to the food strongly enhances intestinal inflammation and colorectal carcinogenesis in two biologically different models of IBD.

We show that EDTA disrupts various components of the intestinal barrier and increases intestinal permeability.
This effect is also present in healthy animals and is likely massively aggravated in the presence of inflammation, leading to impaired wound healing and perpetuation of the inflammatory cascade.

Dysbiosis is also induced by EDTA and it may contribute to the toxic effects. No noticeable toxicity of EDTA in very high doses has been shown in multiple safety testings in healthy animals, leading to the recommended safety doses for human use. The ADI of 1.9 mg EDTA/kg bw recommended by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in 1973 for humans 31 is derived from the NOAEL for rats of 250 mg EDTA/kg bw from the study by Oser et al.32, where 250 mg EDTA/kg bw was the highest concentration used; in other studies doses up to 2500 mg/kg bw have shown no toxicity 5, 33,

Diarrhea as an adverse event has not been described in doses below 250–1000 mg/kg bw 6, 34, 35, which is about three-fold higher than the highest dose in our study.
Although EDTA is capable of disrupting the intestinal barrier in healthy animals as demonstrated by our experiments (Fig.3 b,c), the magnitude of the effect is obviously insufficient to cause a detectible clinical phenotype.

Only for Fe-EDTA, several studies in colitis models have demonstrated an increase in intestinal inflammation and colitis-associated carcinogenesis; but the effect was attributed to iron and not EDTA 8, 36, In line of our findings, Constante et al. noted increased intestinal inflammation in DSS-treated mice with Fe-EDTA but not other iron compounds, concluding that intestinal toxicity might be specific to Fe-EDTA 37,

None of these studies have pointed to EDTA as the specific toxic moiety.
However, while the compound seems safe in a healthy intestine, our results show that this is clearly not the case in the presence of gut inflammation.
Unfortunately, there is no human data in the setting of IBD, infectious diarrhea or colorectal cancer, which, in the light of our study are specific risk populations.

Our study has several limitations. It utilizes only animal and cell culture models, and no data are available on human exposure to EDTA. The disruption of epithelial barrier components in both colitis models is not as apparent as in the healthy mice or in cultured epithelial cell monolayers.

This is most likely due to the time point of sacrifice that was rather late after the initial inflammatory stimulus (in order to better observe tumour development).
It remains not entirely clear how intestinal inflammation enhances EDTA toxicity, as similar changes are observed in healthy mice after a single short-term EDTA exposure.

We hypothesize that a healthy mucosal barrier is more resistant to EDTA, and that a disruption of the barrier components by inflammation exposes deeper and otherwise protected mucosal structures to EDTA and facilitates translocation of commensal intestinal bacteria.

Disruption of the barrier components (mucin 38, 39, tight junctions 40, desmosomes 41, 42, hemidesmosomes 43 ) by genetic defects or by immunological or chemical methods causes intestinal inflammation by itself, which makes it impossible to study these two factors independently in vivo.
A direct effect of EDTA in promoting dysbiosis and therefore inflammation is also possible, as EDTA alters the stability of bacterial cell walls, delays microorganism growth and prevents adhesion by its sequestering action on divalent cations 44,

It remains unclear whether the increased colitis-associated carcinogenesis is solely secondary to inflammation or whether EDTA also has direct procarcinogenic properties. Scheers et al. demonstrated that Fe-EDTA may promote the proliferation of CaCo-2 and Hutu-80 cancer cells by activating Erk via increased levels of amphiregulin and EGFR but not via the Wnt pathway 45,

Studies have also proposed that EDTA may disrupt DNA stability by interfering with DNA-bound proteins by chelating Zn 2+, possibly also Ca 2+ and Mg 2+ 6 ; the functional relevance of such chelation remains unknown. It remains unexplored whether the chelating action of EDTA can influence the intracellular redox balance, thus promoting direct DNA damage.

Nevertheless, the relevance of our findings remains high. EDTA is widely used and very stable. It is detected in most large rivers and even found in the drinking water in concentrations up to 30 µg/l 4, The gastrointestinal (GI) tract would be inevitably exposed to EDTA especially by water together with its use in foods, pharmaceutics, cosmetics and household chemicals.

Because of differences in local regulations and practices, the extent of exposure to EDTA is likely to vary from country to country.
According to our results, due to the presumed EDTA’s toxicity in a specific population (IBD), a lowering and re-determining of the ADI is warranted.
Also, specific recommendations in individuals with GI diseases such as IBD, irritable bowel syndrome, GI cancer or infectious diarrhea should be issued.

It would be important to address the exposure to EDTA in healthy individuals and in patients with the above mentioned conditions in further studies, although studying dietary factors and linking them to a disease phenotype is notoriously problematic due to inconsistent exposure over time, ethical issues preventing a randomized design, difficult data collection and large number of subjects required for a cohort study.

This study also highlights the shortcoming of the way food additive testing is done only in healthy animals. Other food additives and dietary agents have shown relevant intestinal toxicity in the presence of intestinal inflammation that was not apparent in healthy animals, such as emulsifiers 38, TiO 2 46, or most recently polyunsaturated fatty acids 47,

Within the healthy human population itself, disruption of GI barrier function is common and linked to numerous GI conditions as mentioned above. We propose to remove EDTA from ingested substances and to include intestinal inflammatory models in future safety testing.

What is the difference between EDTA and EDTA?

Summary – Disodium EDTA vs Tetrasodium EDTA – EDTA is Ethylenediaminetetraacetic acid. It results in sequestration of metal ions. It binds with metal ions and forms a stable EDTA metal complex. Accordingly, the two forms of EDTA are disodium EDTA and tetrasodium EDTA.

The key difference between disodium EDTA and tetrasodium EDTA is that disodium EDTA has a pH lower than 07 while tetrasodium EDTA has a pH greater than 07.
Furthermore, disodium EDTA contains 2 sodium cations while tetrasodium EDTA contains 4 sodium cations per molecule.
Both compounds are sodium salts of EDTA and are byproducts of EDTA synthesis process.

Thus, this summarizes the difference between disodium EDTA and tetrasodium EDTA.

Why is EDTA used in shampoo?

Role Of Disodium EDTA In Cosmetics – Disodium EDTA is popularly known as a chelating agent and acts as a water-soluble acid which is a strong emulsion stabilizer. It is mainly used in cosmetic products for controlling viscosity. EDTA binds with the metals ions and deactivates them, thus preventing your cosmetic products and other personal care products from degrading or deteriorating.

It is extensively used in creams, body lotions, sunscreens, shampoos, conditioners, styling gels, hair styling sprays and serums.
Disodium EDTA preserves cosmetic products and personal care products from undergoing unwanted changes in texture, colour, pH levels and fragrance.
Apart from binding with metals such as calcium, iron or magnesium, Disodium EDTA helps in enhanced foaming and also exhibits cleansing property.

In beauty and personal care products, EDTA is commonly found in moisturizers, creams, body lotions, hair serums, shampoos, conditioners, hair dyes, hair bleaches and personal care products like soaps and toiletries. In shampoos, bath soaps and hand washes EDTA helps with enhanced foaming and lather formation.

What is a replacement for EDTA in cosmetics?

Chelant/Preservative Potentiation –

Sodium citrate ( EU ) is a natural based chelant ( EU ) produced by fermentation.

NanoChem C-LC/SD-PC (Sodium Polyaspartate) by Nanochem Solutions. Distributed by Deckner Consulting Services, This is a natural polymeric chelant synthesized from fermentation produced L-aspartic acid with a subsequent heating to polymerize. The material also has excellent skin moisturizing and hair conditioning properties. EU: NanoChem C-LC/SD-PC | Deckner Consulting Services

Sodium Phytate by An Kang Shi Mao Biotech Co. Distributed by Deckner Consulting Services. Phytate is the principal storage form of phosphorus in many plant tissues, especially bran and seeds. Sodium phytate is a natural water-soluble chelator that can replace EDTA salts. Sodium phytate also has moisturizing, skin lightening, and oil control properties. It is also useful to help stabilize avobenzone. EU: Sodium Phytate

What effect does EDTA have on hair?

How Is Disodium EDTA Beneficial For Hair Care? – Disodium EDTA is extensively used in many hair care products such as shampoos, conditioners, hair styling gels, hair serums, styling sprays, hair colours, hair dyes, styling mousses because of its beneficial properties. Let’s check how EDTA is beneficial for your hair and how is it effectively used in many hair care products.

Disodium EDTA acts as a chelating agent in hair care products and binds with metal ions in a specific manner such that it deactivates the metal ions, prevents the metals from being deposited on your scalp and hair.
It binds with minerals and forms complexes with minerals such as calcium, magnesium and iron. It enhances the foaming and cleaning properties of your favourite shampoos.
It helps increase the shelf life of your hair care products by retaining its colour, texture and fragrance.
It counteracts the effect of hard water and enhances the foaming and cleansing property of the hair care products.
It binds with the heavy metals ions present in tap water such as calcium, magnesium and chlorine and protects your scalp.
Due to the calcium present in hard water, your shampoo does not lather and does not give the desired effect, but EDTA binds with calcium and strips it off from water and your shampoo is able to perform better.
It does not penetrate your skin or scalp and hence is considered safe for topical use.
It retains the proper formulation of your hair care products and protects it from going rancid.
It exhibits astringent property due to which it helps the hair cuticles in shrinking, thereby making your hair shinier.
It helps to remove debris and the residues of shampoos and conditioners which tend to make your hair look dull.
It acts as a preservative in hair care products as well as a pH adjuster.
It helps to improve the stability of your hair care product as well as its performance.

Because of these incredible properties, Disodium EDTA is used in almost all the hair care products.